MyBioSource.com's Vinculin antibody : F01/4H8 is a Mouse monoclonal antibody. The Vinculin antibody : F01/4H8 was generated using VCL, and Vinculin as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Mouse anti vinculin antibody recognizes vinculin, also known as metavinculin.
Vinculin is a non-ezymatic, cytoplasmic, actin-binding protein that regulates adhesion by stimulating actin polymerization and recruiting actin remodeling proteins. Cell-matrix and cell-cell adhesion are dramatically impaired in the absence of vinculin, revealing its essential role (Bays and DeMali 2017). Vinculin can regulate cell migration, a process determined by cell adhesion and the turnover of focal adhesions. The protein is also required for maintaining integrity of glomerular barriers in the kidney (Lausecker et al. 2018). Downregulation of vinculin has been identified in metastatic cancer cells, and loss of vinculin appears to protect cells from apoptosis (Gao et al. 2017). Therefore, vinculin appears to act as a tumor suppressor and affects tumorigenesis, metastasis, and invasion. In non-small cell lung cancer, vinculin expression is inhibited and this promotes malignancy